Diagnostic and therapeutic approach of systemic amyloidosis.

A case of primary systemic amyloidosis with nail dystrophy

We hereby report a 79-year-old Iranian man presenting with nail dystrophy and subsequent development of purpuric and ecchymotic plaques, hemorrhagic bullae, and infiltrated papules on the head, neck and trunk. Histological examination of the gingiva, bone marrow aspiration, and biopsy confirmed the diagnosis of primary systemic amyloidosis. In this case, nail dystrophy was the presenting sign o...

گزارش یک مورد آمیلوییدوز سیستمیک در حنجره

    Introduction: Amyloidosis is an idiopathic disorder characterized by amyloid deposition leading to tissue damage and disease. Laryngeal amyloidosis is usually a localized phenomenon that is rarely accompanied by systemic involvement. Hoarseness is its most common symptom and the clinical findings in laryngoscopy are variable, nonspecific and difficult to be distinguished from other laryngea...

Multiple Myeloma with HBs Antigenemia Presented with Hoarseness and Systemic Amyloidosis

Systemic Amyloidosis and Testicular Interstitial Tumor in a Zebra Finch (Taeniopygia guttata): a Case Report in Iran

Systemic amyloidosis and testicular interstitial tumor are rare conditions in birds and this is the first report in Iran. A male zebra finch was presented because of white diarrhea, anorexia, loss of weight and lethargy. At necropsy, the small intestine was edematous and congested. The spleen appeared pale. The liver was large, firm and brown. One testis was cystic and neoplastic and the remain...

Systemic amyloidosis: are we moving ahead?

Systemic amyloidoses are a wide group of diseases with different courses, treatments and prognoses. Unequivocal typing of amyloid deposits is important for correct diagnosis and appropriate treatment. At present, the most effective therapeutic approach is based on eliminating the supply of amyloidogenic precursor. New effective therapies will stem from our improved knowledge of the molecular me...